Caspase 3 - Wikipedia
WEBCaspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs [4] have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.
The prodomain of caspase-3 regulates its own removal and caspase …
WEBJan 28, 2019 · Caspase-3 is a cysteine–aspartic acid protease that cleaves cellular targets and executes cell death. Our current understanding is caspase-3 is activated by the cleavage of the...
Caspase-3 Signaling - Cell Signaling Technology
WEBCompany 1 active caspase-3 rabbit monoclonal antibody detects multiple non specific bands at various molecular weights. The antibody recognizes only the 17 kDa band corresponding to one form of the large fragment of cleaved caspase-3.
The caspase-3/GSDME signal pathway as a switch between
WEBOct 28, 2020 · This article mainly reviews the caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer, to provide new strategies and targets for cancer treatment.
Caspase-3: Structure, function, and biotechnological aspects
WEBIn the current review, we intend to discuss the caspase-3's structure, functions, therapeutic applications, as well as its molecular cloning, protein engineering, and relevant delivery systems. Keywords: apoptosis; biotechnology; caspase-3; diseases; therapeutics.
The caspase-3/GSDME signal pathway as a switch between …
WEBOct 28, 2020 · Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the …
Visualization of caspase-3-like activity in cells using a ... - Nature
WEBJul 16, 2013 · With these tools, we monitor in real-time caspase-3-like activity in each cell under various conditions, and show for the first time that the environment of cancer cells affects their...
A Review on Caspases: Key Regulators of Biological Activities and ...
WEBIntroduction. Caspases belong to the conserved cysteine protease enzyme family, which plays vital roles in PCD and inflammation [1]. These enzymes are otherwise known as cysteine-aspartic proteases, cysteine aspartases, …
Paradoxical roles of caspase-3 in regulating cell survival ...
WEBJun 6, 2022 · Caspase-3 is a widely expressed member of a conserved family of proteins, generally recognized for their activated proteolytic roles in the execution of apoptosis in cells responding to specific extrinsic or intrinsic inducers of this mode of cell death.
Cleaved Caspase-3 (Asp175) Antibody - Cell Signaling Technology
WEBCleaved Caspase-3 (Asp175) Antibody detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to Asp175. This antibody does not recognize full length caspase-3 or other cleaved caspases.