Cyclic adenosine monophosphate - Wikipedia
WEBCyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger, or cellular signal occurring within cells, that is important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many …
The cAMP Pathway as Therapeutic Target in Autoimmune and …
WEBMar 31, 2016 · In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders.
Biochemistry, cAMP - StatPearls - NCBI Bookshelf
WEBJul 25, 2023 · Cyclic adenosine monophosphate is a small, hydrophilic molecule commonly known as cyclic AMP or cAMP, which is an important intracellular second messenger molecule regulated in many physiological processes.
The cyclic AMP signaling pathway: Exploring targets for …
WEBMar 18, 2016 · Adenosine 3′,5′-cyclic monophosphate (cAMP) is a nucleotide that acts as a key second messenger in numerous signal transduction pathways. cAMP regulates various cellular functions, including cell growth and differentiation, gene transcription and protein expression.
Cyclic Adenosine Monophosphate - an overview - ScienceDirect
WEBCyclic Adenosine Monophosphate (cAMP) is a molecule that plays a crucial role in intracellular signaling pathways in both prokaryotes and eukaryotes. It is synthesized by the enzyme adenylyl cyclase and primarily activates protein kinase A (PKA), which regulates various cellular processes through protein phosphorylation.
cAMP and cGMP Signaling Cross-Talk | Circulation Research
WEBJun 8, 2007 · Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP.
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, …
WEBApr 1, 2018 · This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs).
WEBRobichaux WG III, Cheng X. Intracellular cAMP Sensor EPAC: Physiology, Pathophys-iology, and Therapeutics Development. Physiol Rev 98: 919–1053, 2018. Published March 14, 2018; doi:10.1152/physrev.00025.2017.—This review focuses on one family of the known cAMP receptors, the exchange proteins directly activated by cAMP
Role of cAMP in Cardiomyocyte Viability: Beneficial or Detrimental?
WEBOct 18, 2023 · Elevating intracellular cAMP, through targeting different GsPCRs (stimulatory-G-protein-coupled-receptors), ACs (adenylyl cyclases), or PDEs (phosphodiesterases), exhibits distinct, even opposing effects on cardiomyocyte viability.
Mechanisms Restricting Diffusion of Intracellular cAMP
WEBJan 22, 2016 · The cAMP signaling pathway plays a fundamental role in regulating a variety of different activities in virtually every cell in our bodies. Cardiac myocytes are a classic example, where cAMP...
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