San Francisco 49ers head coach Kyle Shanahan said he had big comebacks in mind when he kept Christian McCaffrey on the field with his team leading by 19 late in Sunday's game.

As the San Francisco 49ers stormed to a dominant 41–22 win over the Arizona Cardinals, it’s safe to say the scoreline wouldn’t have been nearly as lopsided without tight end George Kittle.

The San Francisco 49ers defeated the Arizona Cardinals 41-22 on Sunday at State Farm Stadium, and head coach Kyle Shanahan spoke after the win.

NFC playoff picture after a big win over the Cardinals. See where San Francisco stands and how the postseason race is shifting.

Mustapha logged four tackles (one solo) and an interception during San Francisco's win over the Cardinals on Sunday.

The San Francisco 49ers took full advantage of an inferior opponent Sunday, marking Brock Purdy's return to action in a 41-22 defeat of the Arizona Cardinals.