An octopus-shaped nanomachine hijacks tumor ATP leakage to power a self-amplifying cycle of membrane damage, drug delivery, and metabolic collapse in cancer cells.

The proton gradients that power respiration are as universal as the genetic code itself, giving an insight into the origin of life and the singular origin of complexity. Why do virtually all cells ...

Cancer cells undergo physically constraining processes, such as intravasation, extravasation, and tissue infiltration, that lead to acute mechanical stress. How mechanical confinement rewires the ...

The way a key cellular motor works at an atomic level has been uncovered by simulations conducted by RIKEN biophysicists.

When cancer cells are physically squeezed, they mount an instant, high-energy defense by rushing mitochondria to the cell nucleus, unleashing a surge of ATP that fuels DNA repair and survival. This ...

The prevalence of kidney disease has been increasing in Japan, with it now affecting one in eight adults, but developing effective treatment remains a challenge. The kidneys are among the most ...

ATP is produced by an enzyme called ATPase, which consists of two molecular motors, F o and F 1, that rotate in opposite ...

Our hearts beat around 100,000 times a day—and do so throughout our entire lives. They draw the energy for this from the ...

Nevertheless, the critical determinant for ciprofloxacin tolerance among genetically distinct persisters is cellular ATP level: lower ATP levels are associated with increased ciprofloxacin tolerance, ...