BIOENGINEER

p53 Reverses Bcl-2’s Pro-Survival Grip by Restoring MAM Function in Skin Cancer

New research in Cell Division shows that Bcl-2 overexpression promotes survival of cutaneous squamous cell carcinoma cells by ...
ascopubs.org

Small molecule pan-bcl-2 inhibitor AT-101 induces apoptosis in NSCLC by up-regulating noxa and enhances antitumor activity of docetaxel or targeted kinase inhibitors

Single nucleotide polymorphisms of TSER, ATM, RecQ1 genes association with survival in pancrease cancer This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not ...
Phys.org

Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein

Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are ...
ascopubs.org

Mebendazole induces apoptosis in distinct melanoma subtypes via Bcl-2 dependent mechanism

Prognostic impact of baseline LDH on survival independent of tumor burden in advanced melanoma: Results of phase III trial of oblimersen-dacarbazine (OBL-DTIC) vs DTIC No significant financial ...
BIOENGINEER

Metformin Clears Aging Cartilage Cells in Lab Study by Unlocking Bak

A laboratory study in immortalized human chondrocytes reports that high concentrations of metformin trigger caspase- and ...