A new kind of CRISPR that destroys cells rather than gene editing them has shown potential for killing sick cells while leaving healthy cells untouched. The technology has largely been tested in cells ...

U.S. patients with sickle cell disease now have a novel treatment option: the first-ever CRISPR-based therapy. Another gene therapy for sickle cell disease, called Lyfgenia and developed by biotech ...

Among the challenges in treating disease, including cancer, is wiping out malignancies, infection, contaminants or other ...

A gene called SDR42E1 has been identified as a key player in how our bodies absorb and process vitamin D. Researchers found that disabling this gene in colorectal cancer cells not only crippled their ...

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

We performed both homology-based and GUIDE-seq nomination of candidate off-target sites, which resulted in the testing of 5002 sites from four healthy donors (not shown). We then nominated additional ...

When activated by its target, the newly characterized molecule rips the genome apart, a lethal move that researchers can ...