Blocking Caspase-2 (the liver’s guardian enzyme) to treat fatty liver may produce chronic damage and multiply the risk of ...

New research has shown that inhibiting caspase-2 to treat fatty liver disease may increase inflammation, fibrosis and cancer ...

Researchers have identified a previously unknown inflammatory mechanism that may drive the aggressiveness and relapse of ...

Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program. This type of cell death is referred to as "programmed cell death". Until ...

Researchers have discovered using mice and human clinical specimens that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive ...

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age. In a major new ...

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...