The primary target of the caspase-9 holoenzyme is procaspase-3, one of the most deleterious effector caspases (Fig. 1). The active caspase-3, composed of a heterotetramer of subunits p17 and p12 ...

HIV-1 Vpu triggers the cleavage of TDP-43 by stimulating Caspase 3 activation. The cleavage products generated can induce the ...

This proapoptotic effect is mediated by caspase-3 and is specific to the liver, suggesting a tissue-specific mechanism of action. Additionally, YopM has been found to reduce the numbers of ...

Despite being a first-line treatment for adolescent depression and anxiety, antidepressant drugs appear to have questionable efficacy and carry an increased risk of adverse effects in this ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex ...

New adventure. New rival. Check out the Sonic The Hedgehog 3 trailer for the upcoming movie starring Jim Carrey, Ben Schwartz, James Marsden, Tika Sumpter, Idris Elba, Colleen O’Shaughnessey ...

Here’s how it works. Little Nightmares 3 is set to arrive next year, following a delay. As such, there's still a lot to learn about the upcoming indie adventure and how it plans to build on the ...

The Apple Watch Series 3 improved upon its predecessors with upgraded components and a model with a cellular connection. The Apple Watch Series 3 is still for sale in 2022, nearly 5 years after ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

The next flagship soundbar from Sonos will be called the Arc Ultra, and marketing images of the product have been posted on X today. They line up with the photos I published back in July and offer ...