Replication timing (RT), the temporal order in which genomic regions replicate, is considered a functional feature of multiple cellular processes and chromatin organization. Two approaches to measure ...

A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and cell-based experiments shows that the enzyme WEE1 switches off ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Curcumae Rhizoma herb pair synergistically enhances 5-fluorouracil against colorectal cancer by disrupting DNA repair and ...

Cancer cells that have lost one safeguard against DNA damage can become dependent on another, an enzyme called Wee1. Drugs ...

Wee1 inhibitors are a promising new cancer treatment, but serious side effects threaten their adoption in the clinic. Now, ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

A study of goat embryos identifies CDK1 as a hub gene whose moderate expression promotes muscle satellite cell proliferation, ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

A study headed by researchers at NYU Langone Health has found that herpes simplex virus 1 (HSV-1) partially liquifies the tightly packed, gel-like interior of human cell nuclei to help copy itself ...

Wee1 inhibitors are a promising new cancer treatment, but serious side effects threaten their adoption in the clinic. Now, researchers from the MRC ...