Sample size determination for case-control studies of chronic disease are often based on the simple 2 x 2 tabular cross-classification of exposure and disease, thereby ignoring stratification which ...

The corrected sample size is necessarily larger than the uncorrected one given by Woolson et al. and the relative difference between the two sample sizes is considerable. Allocation of equal number of ...

This motivates a proxy case–control association study where 'proxy cases' are the relatives of affected individuals and controls are the relatives of unaffected individuals.