Scientists have identified for the first time specific genes in the brain that are affected by the lack of FMRP — the protein that is absent in individuals with fragile X syndrome, the most frequent ...

Collaboration with UMass Chan Medical School confirmed FMR1-217 as well as an RNA-targeted mechanism to restore functional FMRP protein to develop potential treatments for FXS QurAlis’ preliminary ...

Research on fragile X syndrome, the most common inherited cause of mental retardation, has focused mostly on how the genetic defect alters the functioning of neurons in the brain. A new study focusing ...

Now a collaborative research effort at Duke University Medical Center and Rockefeller University has pinpointed the precise genetic footprint that links the two. The findings point the way toward new ...

Salk neuroscientists found how specialized brain cells called astrocytes contribute to fragile X syndrome symptoms: through a protein pathway that, when suppressed, can alleviate some symptoms in a ...

Fragile X syndrome (FXS) is an inherited genetic developmental condition that strongly impacts brain development. Despite the ...

Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, is caused by silencing of the Fmr1 gene, leading to a lack of the FMRP protein, which regulates protein ...

Researchers discovered that suppressing BMP signaling in astrocytes reduces seizures and restores brain balance in Fragile X syndrome models.