Sensing pain is extremely unpleasant and sometimes hard to bear - and pain can even become chronic. The perception of pain varies a lot depending on the context in which it is experienced. 50 years ...

The spinal cord transmits pain signals to the brain, where they are consciously perceived. But not all the impulses arrive at their destination: Certain neurons act as checkpoints and determine ...

The gate control theory of pain, put forward by Ron Melzack and Patrick Wall in 1962, is the idea that physical pain is not a direct result of activation of pain receptor neurons, but rather its ...

One of the critical developments in the history of pain research has been the publication of the gate control theory by Ronald Melzack and Patrick David Wall. First developed in the early 1960s, the ...

Aβ-LTMRs are further divided into rapidly adapting (RA) and slowly adapting (SA) types based on their firing patterns in response to a sustained mechanical stimulus. At baseline conditions, ...