Close collaboration between academic and industrial groups is vital to ensuring glycosylation models are fit for deployment. Many of the highest-grossing protein therapeutics, including monoclonal ...

Over the past decade, notable advances in the control of post-translational modifications to enhance therapeutic properties have continued to drive the development of many next-generation ...

A new study by researchers from Taiwan and the US suggests that the removal of unnecessary glycans from spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposes ...

Sample preparation tends to be manually labor intensive, but automating this step helps streamline the glycosylation monitoring workflow. Biopharmaceutical analysis is one area in biopharma drug ...

GEN: Accurate glycosylation is essential for proper functioning of monoclonal antibodies (mAbs) generated in vitro. What are the advantages and disadvantages of using engineered bacterial or yeast ...

Bacterial protein glycosylation systems encompass a diverse array of enzymatic mechanisms responsible for the covalent attachment of carbohydrate moieties to proteins. These modifications, which ...

Carbohydrate chemists and biochemists tend to be controlling personalities. They aren't satisfied with the way sugar groups are attached naturally to glycosylated proteins and natural products. These ...

Furthermore, the scientists expressed spike protein (similar to vaccine candidate) in mammalian cells and compared its glycosylation process with the virus-derived spike protein. Interestingly, the S1 ...

Deep in our cells, a wide range of processes are occurring constantly. These cellular processes rely on enzymes to act as catalysts and set off a series of molecular interactions. There are still many ...

Glycans can enhance, dampen or redirect protein activity. Glycan modification can alter size, charge and geometry, shield an enzyme from degradation, help a hormone find its receptor or steer an ...