A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

Alpha-substituted fatty amines and nitrogen-containing heterocycles are widely found in numerous bioactive natural products, pharmaceutical molecules, and agrochemicals. A recent analysis of small ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...

It’s hard to improve on a classic. But Richard Y. Liu was eager to take on that challenge. Cross-coupling reactions, including Suzuki-Miyaura coupling and Buchwald-Hartwig amination, are some of the ...

Scheme shows the reduction of a nitroaromatic molecule with an aldehyde and chlorine to the corresponding aromatic amine. A simple reaction can increase the value of a small molecule more than 10 ...