Oral presentation includes early readouts from preclinical testing of CAR-encoding episomal DNA delivered by targeted lipid nanoparticlesCPTx ...

From vaccines to personalized cancer therapies, scientists are studying the use of mRNA across many clinical applications. However, there are several factors that are unique to mRNA drug product ...

A trio of common amino acids may hold the key to unlocking far more powerful gene therapies. Researchers found that adding them to lipid nanoparticles can boost mRNA delivery up to 20-fold and push ...

Lipid nanoparticles address key drug delivery challenges, including immune evasion, toxicity, and regulatory approval.

Researchers at the Icahn School of Medicine at Mount Sinai say they have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a ...

Developers are increasingly exploring non-viral gene delivery methods as safety issues with viral vectors draw scrutiny. Advances in lipid nanoparticles, polymer carriers, and electro-transfection are ...

A new study shows that lipid nanoparticles restructure their membrane significantly after being absorbed into a cell and ending up in an acidic environment. (Nanowerk News) Vaccines and other ...

Researchers have used artificial intelligence to design ionizable lipids that outperform current gold-standard molecules in delivering mRNA, a key technology in vaccines and gene therapies. The ...

Liposomes and lipid nanoparticles (LNPs) are versatile drug delivery systems that allow precise control over composition, morphology, and structure, tailoring these features to meet specific ...

Penn Engineers have redesigned a key component of lipid nanoparticles (LNPs), the delivery vehicles behind mRNA vaccines, to steer the particles toward lymph nodes while reducing off-target delivery ...

Better mRNA release inside cells boosts vaccine and gene editing performance, enabled by redesigned lipid molecules that grip cargo tightly but let go quickly once inside cells. For vaccines, this was ...