Here we present a statistical framework for estimating the genotype-specific risks for disease in such families using the method of maximum likelihood conditioned on the mating type of the parents.

Often maximum likelihood is the method of choice for fitting an econometric model to data but cannot be used because the correct specification of the (multivariate) density that defines the likelihood ...

This example calculates confidence intervals based on the profile likelihood for the parameters estimated in the previous example. The following introduction on profile-likelihood methods is based on ...