What just happened? What does it mean? What are the pertinent factors (and, perhaps, tiebreakers) prominently in play as each conference's seven-team bracket begins to crystallize? All will be explained and analyzed up to the point when the postseason field is finalized on Sunday,

San Francisco 49ers wide receiver Brandon Aiyuk hasn't been on the field this year, but he's been a frequent topic of conversation.

The Indianapolis Colts host the San Francisco 49ers on 'Monday Night Football' in NFL Week 16 action: Injury report.

The San Francisco 49ers have a perfect post-Bye Week opener. Not only do they get to play a game at home, but they face arguably the worst team in the NFL, the

The Arizona Cardinals are having one of their worst seasons in recent history, and it is happening when the NFC West might be having its best year. The Los Angeles Rams, Seattle Seahawks and San Francisco 49ers all have at least 10 wins. All are on track to make the playoffs and all have a real shot at the top seed in the conference.

The 49ers and Rams faced off in the NFC title game in January of 2022 with Los Angeles punching their ticket to the Super Bowl. Matthew Stafford out dueled Jimmy Garoppolo, while Los Angeles scored 13 unanswered points in the fourth quarter to win.

The Carolina Panthers and San Francisco 49ers clash to wrap NFL Week 12 on Monday night at 8:15 p.m. ET. Bryce Young is surging for the Panthers, but it’s a “revenge game” for Christian McCaffrey against his former team. Young had three touchdowns in ...

The Tennessee Titans will take on the San Francisco 49ers in Week 15 action. Here is one person that could give the Titans a boost.

There were two big changes made to the Indianapolis Colts' second Week 16 injury report. First, Alec Pierce was listed as limited on Thursday with an Achilles injury. However, on Friday, he was upgraded to being a full participant.