DNA polymerase ζ (Polζ) has emerged as a key reverse transcriptase in RNA-templated double-strand break repair (RT-DSBR), beyond its canonical role in translesion DNA synthesis (TLS). We present here ...

DNA polymerases are central to the faithful duplication and maintenance of the genome. Beyond replication, specialised polymerases are recruited to distinct repair pathways to restore integrity after ...

Three biochemical steps of the non-homologous DNA end-joining (NHEJ) process. This figure outlines the key stages of the NHEJ repair mechanism following DNA double-strand breaks. The process can be ...

I. Platinum-based therapies induce DNA inter-strand crosslinks (ICLs), which exacerbate genomic instability and impede DNA replication. In BRCA1/2-deficient tumor cells, the repair of these DNA ...

Preclinical assays found that NU7441 displaced BRD4 from acetylated chromatin and impaired homologous recombination and ...