Mutations in the PINK1 gene are a frequent cause of autosomal recessive Parkinson’s disease (PD). PINK1 encodes a mitochondrial kinase with neuroprotective activity, implicated in maintaining ...

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway. Mitophagy is an essential part of mitochondrial quality control and plays ...

Clear cell renal cell carcinoma (ccRCC) is a common type of cancer in the urinary system. Currently, the first-line treatments for advanced or metastatic ccRCC are tyrosine kinase inhibitors (TKIs); ...

Growing evidence points to mitochondrial quality control as a key feature of familial Parkinson’s disease (PD) and related disorders. An August 11 Nature Neuroscience paper bolsters that notion.

Researchers have zeroed in on a mechanism that may promote the earliest stages of mitochondrial decline in Parkinson’s disease (PD). Mutations that hinder the kinase activity of the ...

Cells are powered by tiny energy reactors called mitochondria. When damaged, they leak destructive molecules that can cause substantial harm and eventually kill brain cells. A protein called PINK1 ...

Our most recent work is focused on elucidating how a protein kinase (PINK1) controls the activity of a ubiquitin E3 ligase (Parkin) to specify cell fate decisions. Mutations in genes encoding for ...

Add Yahoo as a preferred source to see more of our stories on Google. Scientists have made a potentially “life-changing” discovery that could pave the way for new drugs to treat Parkinson’s disease.

WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition. First ...

Somewhere in the tangle of a brain under siege by Parkinson’s disease, immune cells appear to be doing something remarkable: ...