New findings define a pathway that maintains PTEN in the nucleus and offer a novel target for enhancing this gene's tumor suppressive function. The PTEN tumor suppressor gene controls numerous ...

PTEN Research today announced the launch of ‘PTEN Connect’, a new clinical trial of the mTOR inhibitor everolimus designed to ...

PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to ...

Discover the latest articles and news in related subjects. In this report, we provide evidence that depletion of PTEN impairs chromosome congression leading to markedly increased incidences of ...

Loss of function of the PTEN tumor suppressor gene leads to resistance to therapies targeting the Notch signaling pathway according to a mouse study presented at the 2016 Society of Gynecologic ...

Among the 66 patients analyzed, 11 received a combination of BRAF and MEK inhibitors for the treatment of melanoma. Among the 55 patients treated with BRAF inhibitor monotherapy, objective responses, ...

High levels of a polyubiquinated form of phosphatase and tensin homolog (PTEN) were associated with an almost four-fold higher risk of a 40% decline in kidney function in a cohort of American Indians ...

PTEN, a tumor suppressor gene mutated in about 20% of prostate cancers, relies on another gene, ARID4B, to function. PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate ...

Newswise — The PTEN tumor suppressor gene controls numerous biological processes including cell proliferation, cell growth and death. But PTEN is frequently lost or mutated; in fact, alteration of the ...

PTEN, a tumor suppressor gene mutated in approximately 20% of primary prostate cancers, and in as many as 50% of androgen deprivation-resistant prostate cancers, relies on another gene, ARID4B, to ...