Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

Perhaps you’ve read in a biology textbook that humans have the same number of genes as C. elegans, a worm used in scientific research. Perhaps you’d also like to believe that humans are more complex ...

A selective protein degradation system known as Golgi membrane-associated degradation (GOMED), which identifies and removes ...

Unstable proteins are the main drivers of many different heritable diseases, according to a new study, including genetic disorders responsible for the formation of cataracts, and different types of ...