The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...

Quantitative proteomics currently encompasses a variety of techniques including differential labeling of separate protein mixtures; digestion of combined, labeled protein mixtures such as cell lysates ...

A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...

Mass spec is now the technique of choice for the complex challenges of protein identification. In earlier years, the unraveling of protein amino acid sequences by Edman degradation was the preferred ...