Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...

Structural mass spectrometry has emerged as a powerful approach to elucidate the three‐dimensional conformations of proteins and their complexes under near‐physiological conditions. In particular, ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding where ...

Technological advances in mass spectrometry are aiding researchers to image and characterize protein and other cellular components with increasing resolution. Using native ambient mass spectrometry ...

A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...

A typical protein identification workflow using MS involves digesting proteins into peptides and analyzing them using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) on a high-resolution ...

In this article, we examine how multiomics is advancing disease research, particularly in neurodegenerative disorders such as ...

As our bodies run multiple parallel processes, they shuttle a flurry of messages around inside—often as protein-metabolite interactions (PMIs), where small molecules bind to a protein and initiate or ...

Antibodies are the immune system's precision tools for recognizing and neutralizing viruses, bacteria and other foreign ...

Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101). Background: To evaluate SELDI as a potential technique for predicting response to ...

New study reveals how mass spectrometry can be used to determine the mechanisms used by molecular glues to stick to their targets. Molecular glues are a continually expanding area of medicinal ...