Cooperative binding processes are widespread in Nature and are important for regulation of key enzymes and receptors. In general, cooperativity is controlled by an allosteric response to ligand ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Allosteric ligands interact with binding sites on the receptor molecule that are topographically distinct from the binding site for the endogenous agonist (the orthosteric site). Allosteric modulators ...

We explore what allosteric modulators are, their benefits and drawbacks, and which candidates are currently advancing through ...

G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. Through spatially distinct, but conformationally linked, binding sites they have evolved to transduce signals from one part ...

Professor Nicolas Doucet and his team at Institut national de la recherche scientifique (INRS) made a major breakthrough earlier this year in the field of evolutionary conservation of molecular ...