Cooperative binding processes are widespread in Nature and are important for regulation of key enzymes and receptors. In general, cooperativity is controlled by an allosteric response to ligand ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Allosteric ligands interact with binding sites on the receptor molecule that are topographically distinct from the binding site for the endogenous agonist (the orthosteric site). Allosteric modulators ...

We explore what allosteric modulators are, their benefits and drawbacks, and which candidates are currently advancing through ...