To restore or reset Microsoft Excel to default settings, open the Registry Editor and simply delete the Options key located here.

Microsoft Excel provides a way for you to personalize the spreadsheets your business uses to your liking and save those customizations as the standard default settings. At some point, if you want ...

However, you eventually may find that you want to again use the default shortcuts. In this case, you can reset the shortcut keys in the Microsoft Excel "Tools" menu.