Researchers found that KAT7 promotes CMPK2-driven mitochondrial DNA release in microglia, activating inflammatory cGAS-STING ...

In a new study published in Science Signaling titled, “Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson’s linked-LRRK2 mutant mice,” researchers from ...

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, ...

The research details how neurons and glial cells utilize leucine-derived acetyl-coenzyme A (AcCoA) rather than canonical amino acid sensing pathways to regulate mTORC1, the master signaling hub ...

A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, ...

Irisin, a hormone released during exercise, appears to directly shield neurons from damage in a mouse model of multiple ...

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4). This protein can guide ...

Ferroptosis, a type of cell death, may help maintain neuron balance in the hippocampus, supporting memory, learning and brain ...

A new study discovers a dedicated mechanical itch pathway linked to peach fuzz hairs, opening new targets for eczema treatment.

Having a companion nearby can make intimidating situations feel less daunting to mammals. New research in mice reveals the ...