Barcelona researchers have created an algorithm for studying protein aggregation and mutating proteins from AlphaFold.

Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson's disease. Researchers have used ...

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows study. Rather, the formation of protein into liquid droplets ...

Protein stabilization is key to tackling protein aggregation, which is involved in neurodegenerative diseases. Rajan et al. explore molecular mechanisms by which zwitterionic polymers stabilize ...

Raghu R. Chivukula, MD, Ph.D., a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is ...

Protein-based therapeutics have transformed treatments for numerous diseases, yet their production remains highly complex and cost-intensive [1][2],[3][4]. Downstream processing (DSP), including ...

Large protein machines in the body carry out many of the cell's most essential tasks, from energy production to the regulation of signal transmission. Although they can now be imaged in great detail ...

Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link ...

In patients with Huntington’s disease, proteins misfold and clump together. Researchers imagine the treatment could potentially someday be administered as a once-weekly injection to delay disease ...

The formation of protein amyloid fibrils in the brain is a hallmark of various neurodegenerative diseases, including Alzheimer diseases and Parkinson diseases. Amyloid f ...