Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

Using engineered zinc-finger nucleases—DNA-binding proteins that target specific sequences—researchers at a biotechnology company report this week in an advanced online publication in Nature that they ...

Zinc finger nucleases (ZFNs) have great potential for translational research and clinical use. Scientists succeeded in the efficient construction of functional ZFNs and the improvement of their genome ...

Engineered nucleases have created unprecedented possibilities for targeted genome editing in numerous species and cell types that were once beyond the reach of targeted genome-editing approaches.

Gene editing strategies, from epigenetic engineering to cell reprogramming and genetic vaccines, are accelerating the development of new therapies that awaken the immune system to treat cancer, as ...

A, B) Zinc finger nucleases (ZFNs) and transcription activator-like effect nucleases (TALENs) edit genome by programmable protein binding to targeting site. (C) Clustered regularly interspaced short ...