Lara Trump, who ruled out a Senate run in Florida earlier in the year, would likely be the frontrunner if she entered. Other potential contenders, like Rep. Pat Harrigan said Tuesday in a post on X that he would back Lara Trump if she chose to run.

"Leaders who are willing to embrace bipartisanship, compromise, and demonstrate independent thinking are becoming an endangered species," the senator wrote in a statement

North Carolina Sen. Thom Tillis' surprise retirement announcement over the weekend creates a sudden opening in next year's midterm elections.