The multicomponent mRNA-1083 vaccine elicited noninferior immune responses in adult patients when compared with coadministered influenza and COVID-19 vaccines.

In this episode presented by Eclipsebio, BioSpace's head of insights Lori Ellis discusses mRNA and srRNA with Andy Geall of ...

Figure 3 Expression of caspase-3 is suppressed by lentiviral caspase-3-shRNA after treatment with 1% fetal bovine serum for 48 h, with β-actin used as an internal control. A, Quantitative analysis of ...

IL2–caspase 3 was tested both for its ability to prevent the development of colitis, and for its therapeutic potential to cure on-going, active acute disease. In addition, colon tissue samples were ...

Therapies involving mRNA, a key to Covid vaccines, hold great potential in treating several diseases, but some lawmakers want to ban them and the government is cutting funding.

Besides, the cardiac tissues of the ASC, Nlrp3, Caspase-1, GSDMD mRNA and Caspase-1 and GSDMD protein expression were significantly elevated (P < 0.05). Compared with the model group, the staining and ...

Apoptotic caspases, including caspase-3, -6, -7 and -8, cleave DRP1 at the motifs of D 500 FAD 503 and/or AEAD 556, suggesting that this cleavage event may occur during infection of different viruses.

We noted that siCaspase-3 treatment led to a much weaker caspase-3 activity (Figures 4E,F), which was apparently attributed to decreased levels of pro-caspase-3 mRNA and protein, different from the ...

Human cells respond to cytoplasmic mRNA depletion during early apoptosis by inhibiting RNA polymerase II transcription, thereby magnifying the gene expression shutdown during stress.

The amount of the DNA fragments detected in the supernatants showed the extent of apoptosis in the sample. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) The qRT-PCR technique was used to ...

Whereas levels of processed caspase‐11 and its downstream caspase‐1 were elevated in GPx8−/− BMDMs, the amounts of caspase‐11 protein (Fig 3 F, lanes 1 and 6) and mRNA (Fig 3 G) in priming conditions ...