As reported in 1994, the original SOD1-G93A strain, designated G1, expressed approximately 18 copies of human SOD1, randomly inserted into the genome (Gurney et al., 1994). An unequal crossover event ...

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Sensory Stimulation Systems, and GENUS, refer to a noninvasive procedure, i.e., a "digital therapeutic," being developed by Cognito Therapeutics. The company developed a wearable GammaSense ...

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

Up-and-coming Alzheimer’s blood tests may soon be used for people with Down’s syndrome. In a longitudinal biomarker study of adults with three copies of ...

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

In mice, exercise spurred neurogenesis in wild-type and APP/PS1 mice. The workouts induced protective gene-expression signatures across cell types in the dentate gyrus. Exercise reversed some of the ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...

Award Application budget is limited to $10.35 million in direct costs per year. The project period is five years.

Award Application budgets are not limited but need to reflect the actual needs of the proposed project. The maximum project period is 5 years.

Award Application budgets are not limited but must be commensurate with the scope of the proposed research. The maximum project period is five years.