Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino …

By recruiting several proteins that bind actin filaments, the cytoplasmic tails mediate the integrin-cytoskeletal connection, which is essential for most, if not all, integrin mediated functions (see …

Jan 2, 2023 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational …

Jul 20, 2025 · Integrin-mediated adhesion and signaling are fundamental to many bodily functions. During wound healing, for instance, integrins guide skin cells (keratinocytes) to …

May 1, 2020 · We focus on more recent advances in conformational regulation and thermodynamics of integrin activation, and on a subset of the key protein-protein interactions …

Nov 30, 2023 · The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. Integrins function as adhesion receptors for extracellular …

Integrin-ligand combinations can be clustered into four main classes, based on the nature of the molecular interaction. All five αV integrins, two β1 integrins (α5, α8), and αIIbβ3 recognize …

The αβ pairings of integrin subunits dictate the specificity of the integrin to a particular ligand, modulate the formation of intracellular adhesion complexes, and regulate downstream signaling.

Integrin adaptor proteins function to link integrin to the actin and microtubule cytoskeletal network, which helps integrins to modulate the regulation and organisation of the cytoskeleton.

Inactive conformation of integrin (left) and a hypothetical model of the open, active form (right), with a fibrinogen peptide in red and a talin domain in magenta.