mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation
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Protein, Leucine & mTOR: Balance for Longevity 🧬💪 mTOR is a master growth switch. Leucine-rich protein (and insulin) turns it on—great for muscle, recovery, and metabolic health. Turning it down at times—via fasting, lower protein windows, polyphenols, or exercise-induced AMPK—supports cellular repair, autophagy, and lifespan (seen across multiple model organisms). The playbook isn’t “always on” or “always off.” It’s strategic cycling: • Hit a leucine threshold (~2–3 g) with 30–50 g high-quali
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