The misuse of Null Hypothesis Statistical Testing (NHST) goes way beyond p-value abuse in research papers. It creeps into metaphysical arguments, where people slap it on like a lab coat for fake sophistication, while completely misunderstanding how it actually works (exhibit A QT'd post)The null hypothesis is not some universal default that every rational observer with “neutral priors” is supposed to believe. It’s simply the working hypothesis you set up to test against an alternative, in a spec
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The misuse of Null Hypothesis Statistical Testing (NHST) goes way beyond p-value abuse in research papers. It creeps into metaphysical arguments, where people slap it on like a lab coat for fake sophistication, while completely misunderstanding how it actually works (exhibit A QT'd post)The null hypothesis is not some universal default that every rational observer with “neutral priors” is supposed to believe. It’s simply the working hypothesis you set up to test against an alternative, in a spec
108 views2 weeks ago
x.comLimit and Mind
If US frontier models pause for long enough,* we may get a natural experiment to test the distillation hypothesis.If Chinese models stop making progress, then it was mostly distillation.But if they keep making progress and even surpass the public versions of US frontier models, then there are real drivers of Chinese model progress beyond distillation.*A big caveat would be the length and fullness of the pause. If it’s too short (less than 12 months?) or not all US frontier labs pause, then it wo
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If US frontier models pause for long enough,* we may get a natural experiment to test the distillation hypothesis.If Chinese models stop making progress, then it was mostly distillation.But if they keep making progress and even surpass the public versions of US frontier models, then there are real drivers of Chinese model progress beyond distillation.*A big caveat would be the length and fullness of the pause. If it’s too short (less than 12 months?) or not all US frontier labs pause, then it wo
77.1K views2 weeks ago
x.comKyle Chan
AI agents just started doing real science, not just answering questions. Most AI research agents follow one path or take orders from a central planner. They forget what failed and stop improving once they plateau.AutoScientists works differently. It is an open-source team of agents that runs experiments for hours or days.No central boss exists here. Agents read a shared state, debate ideas on a forum, then critique each other before spending compute.They self-organize around promising leads. Whe
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AI agents just started doing real science, not just answering questions. Most AI research agents follow one path or take orders from a central planner. They forget what failed and stop improving once they plateau.AutoScientists works differently. It is an open-source team of agents that runs experiments for hours or days.No central boss exists here. Agents read a shared state, debate ideas on a forum, then critique each other before spending compute.They self-organize around promising leads. Whe
1.5K views3 weeks ago
x.comAlphaSignal AI
Imagine you had the energy, metabolism, and mental agility of your younger self - without the aches and pains that come from aging.That’s what we’re attempting to build at @NewLimit and it will be one of the most important achievements in human history ever if it works. We're on the cusp of this being tractable given the rise of AI to test more hypotheses in-silico, along with the rapidly falling cost of single cell sequencing, etc.We announced our Series C and upcoming human clinical trials thi
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Imagine you had the energy, metabolism, and mental agility of your younger self - without the aches and pains that come from aging.That’s what we’re attempting to build at @NewLimit and it will be one of the most important achievements in human history ever if it works. We're on the cusp of this being tractable given the rise of AI to test more hypotheses in-silico, along with the rapidly falling cost of single cell sequencing, etc.We announced our Series C and upcoming human clinical trials thi
199.6K views3 weeks ago
x.comBrian Armstrong
LE MYSTÈRE DE L’ANTARCTIQUE🛑 Continent et/ou passage gardé vers un autre monde🛑 Principe clé: interdiction d’accès aux peuples, aux pays et leirs dirigeants🛑 Sous contrôle sévère de qui y accède🛑 Un traité signé en 1959 pose de nombreuses questions: pourquoi un traité? avec qui? quels en sont les clauses? quand cette “douane” a-t-elle été établie historiquement?🛑 Un autre accord aurait été signé par l’Antarctique avec John Kerry et le Vatican (ça sent pas bon?!) ..il y a quelques années…j’a
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LE MYSTÈRE DE L’ANTARCTIQUE🛑 Continent et/ou passage gardé vers un autre monde🛑 Principe clé: interdiction d’accès aux peuples, aux pays et leirs dirigeants🛑 Sous contrôle sévère de qui y accède🛑 Un traité signé en 1959 pose de nombreuses questions: pourquoi un traité? avec qui? quels en sont les clauses? quand cette “douane” a-t-elle été établie historiquement?🛑 Un autre accord aurait été signé par l’Antarctique avec John Kerry et le Vatican (ça sent pas bon?!) ..il y a quelques années…j’a
117.1K views2 weeks ago
x.comDr Astrid Stuckelberger
“When a hypothesis is retracted, we’ve lost science and medicine.”Testifying before the Senate, Dr. Sabine Hazan discussed her research on the gut microbiome and its potential relationship to a wide range of diseases.According to Dr. Hazan:• Severe COVID-19 patients were found to have lower levels of bifidobacteria.• Reduced bifidobacteria levels were also observed in conditions including autism, Alzheimer’s disease, Crohn’s disease, Lyme disease, irritable bowel syndrome, certain mental health
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“When a hypothesis is retracted, we’ve lost science and medicine.”Testifying before the Senate, Dr. Sabine Hazan discussed her research on the gut microbiome and its potential relationship to a wide range of diseases.According to Dr. Hazan:• Severe COVID-19 patients were found to have lower levels of bifidobacteria.• Reduced bifidobacteria levels were also observed in conditions including autism, Alzheimer’s disease, Crohn’s disease, Lyme disease, irritable bowel syndrome, certain mental health
240 views2 weeks ago
x.com24Medico.com
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