This World Amyloidosis Day, Anna Olliff-Cooper shares her AL amyloidosis story with us to help raise awareness. Anna was diagnosed following several troubling symptoms, such as fractured ribs, pain, recurring infections and fatigue, even mouth ulcers. AL amyloidosis is a relatively rare condition, which few people have heard of before they, or a friend or family member, receives a diagnosis. This can often leave people feeling anxious about what to expect and uncertain about the future. Anna rem

AL amyloidosis animation | misfolding immunoglobulin light chains | amyloid deposits

Cardiac Amyloidosis Definition Cardiac amyloidosis is an infiltrative restrictive cardiomyopathy caused by deposition of misfolded amyloid fibrils in the myocardium, leading to stiff, noncompliant ventricles and progressive heart failure with preserved ejection fraction (HFpEF). Major Types Affecting the Heart 1--AL (Light Chain) Amyloidosis Derived from immunoglobulin light chains (κ or λ). Associated with plasma cell dyscrasias (e.g., multiple myeloma). Rapid progression; median survival witho